%0 Journal Article %A Cissé, Mamoudou Cissé %A Sirima, Constant Sirima %A Gomgnimbou, Michel K. Gomgnimbou %A Traoré, Isidore T. Traoré %A Drabo, Hamed Drabo %A Sanou, Arnaud Q. Sanou %A Silga, Edmond W. Silga %A Soulama, Alamissa Soulama %A Kornu, Victor E. Kornu %A Anshah, Felix Anshah %A Djibougou, Arthur D. Djibougou %A Diallo, Ismael Diallo %A Zida, Adama Zida %A Sangaré, Ibrahim Sangaré %A Bamba, Sanata Bamba %A Aniweh, Yaw Aniweh %A Zongo, Issaka Zongo %A Awandare, Gordon A. Awandare %D 2025 %J African Journal of Parasitology, Mycology and Entomology %@ 1987-1473 %V 3 %N 1 %P 3 %T Diagnostic Performance of NxTek™ Eliminate Malaria-Pf Test for the Detection of Plasmodium falciparum Infection in Pregnant Women from Bobo-Dioulasso, Burkina Faso %M doi:10.35995/ajpme03010003 %U https://ajpme.jams.pub/article/3/1/283 %X Introduction: Knowledge gaps still exist in Burkina Faso regarding the diagnostic performance of the highly sensitive rapid diagnostic test (hsRDT) for the detection of Plasmodium (P.) falciparum malaria infection in pregnant women during antenatal care visits in Bobo-Dioulasso city. Methods: A cross-sectional study including 288 pregnant women was conducted between October and December 2022. P. falciparum malaria infection in peripheral blood was detected using the hsRDT, conventional RDT (cRDT), microscopy, and an ultrasensitive quantitative polymerase chain reaction (qPCR). The hsRDT, cRDT, and microscopy performance were assessed using qPCR as the gold standard. Cohen’s Kappa test was used to estimate the agreement between the different diagnostic tests. Results: The prevalence of P. falciparum infection was 59.72% (172/288) by qPCR. The sensitivity of the hsRDT, cRDT, and microscopy was 51.16% [95% CI (43.44–58.85)], 50.58% [95% CI (42.87–58.28)], and 32.56% [95% CI (25.62–40.11)], respectively. The specificities were 98.28% [95% CI (93.91–99.79)], 99.14% [95% CI (95.29–99.98)], and 99.14% [95% CI (95.29–99.98)] for the hsRDT, cRDT, and microscopy, respectively. The agreement between the hsRDT and qPCR was moderate (Kappa = 0.44; p < 0.001). For parasite density by qPCR below 100 parasites/µL, the hsRDT and cRDT had the same sensitivity of 28.81% [95% CI (20.85–37.87)] but higher than that of microscopy [5.93% (95% CI 2.42–11.84)]. Conclusions: The sensitivity of the hsRDT is similar to that of the cRDT but better than that of microscopy. These results highlight the need for further studies to better guide recommendations on using the hsRDT malaria control and elimination.