Increase in Adherence and Efficacy of Intermittent Preventive Treatment (IPT) with Sulfadoxine–Pyrimethamine Among Pregnant Women in Bouna from 2021 to 2024
1 Department of Parasitology-Mycology-Animal Biology-Zoology UFR Pharmaceutical and Biological Sciences, Félix Houphouët-Boigny University, Abidjan BPV 34, Côte d’Ivoire; (A.K.-T.); (A.H.V.-B.); (A.J.S.M.); (E.G.M.K.); (F.K.K.); (P.M.C.K.-B.); (E.K.A.); (V.D.); (H.E.M.); (W.Y.)
2 Malaria Research and Control Center, National Institute of Public Health, Abidjan PBV 47, Côte d’Ivoire
* Author to whom correspondence should be addressed.
Received: 30 Sep 2025 / Accepted: 22 Jun 2026 / Published: 10 Sep 2026
Abstract
Introduction: There are limited scientific data on the effectiveness of malaria control strategies among pregnant women in Bouna. This study was initiated to evaluate the efficacy of Intermittent Preventive Treatment with Sulfadoxine–Pyrimethamine (IPT-SP) among pregnant women in Bouna from 2021 to 2024. Methods: This study compiled data from two cross-sectional studies assessing the effectiveness of IPT-SP. These studies involved parturients received at the maternity ward of Bouna General Hospital in 2021 and 2024. Data were collected using a structured questionnaire, and plasmodial infestation was detected through optical microscopy. Results: The adherence rate for the third dose of SP (SP3) was 59.6% (143/240) in 2021 compared with 62.1% (149/240) in 2024. Plasmodial indices in 2021 were 13.8%, 11.7%, 8.3%, and 11.3% in venous blood, placental blood, cord blood, and placental smear, respectively, compared to 6.7%, 5.8%, 2.1%, and 6.3% in 2024. Data analysis revealed that attending fewer than four antenatal care (ANC) visits was associated with a low adherence rate to IPT-SP (2021: OR = 6.07; CI: [3.05–12.08]; p = 0.0001; 2024: OR = 43.66; CI: [20.29–93.98]; p = 0.0001). Factors such as maternal age (2021: p = 0.034; 2024: p = 0.030), parity (p = 0.001), gravidity (2021: p = 0.0001; 2024: p = 0.009), IPT-SP intake (2021: p = 0.032; 2024: p = 0.031), presence of anomalies (p = 0.003), and plasmodial infestation were associated with the occurrence of low birth weight. Conclusion: This study confirms the efficacy of IPT-SP. However, regular monitoring of its effectiveness and the exploration of new strategies for malaria control among pregnant women are recommended.
Keywords: plasmodial infestation; pregnant women; Sulfadoxine–Pyrimethamine; Côte d’Ivoire
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CITE
Bédia-Tanoh, A.V.; Konaté-Touré, A.; Vanga-Bosson, A.H.; Miezan, A.J.S.; Koné, E.G.M.; Kassi, F.K.; Kiki-Barro, P.M.C.; Angora, E.K.; Djohan, V.; Menan, H.E.; Yavo, W. Increase in Adherence and Efficacy of Intermittent Preventive Treatment (IPT) with Sulfadoxine–Pyrimethamine Among Pregnant Women in Bouna from 2021 to 2024. AJPME 2026, 4, 3.
Bédia-Tanoh AV, Konaté-Touré A, Vanga-Bosson AH, Miezan AJS, Koné EGM, Kassi FK, Kiki-Barro PMC, Angora EK, Djohan V, Menan HE, Yavo W. Increase in Adherence and Efficacy of Intermittent Preventive Treatment (IPT) with Sulfadoxine–Pyrimethamine Among Pregnant Women in Bouna from 2021 to 2024. AJPME. 2026; 4(2):3.
Bédia-Tanoh, Akoua Valérie; Konaté-Touré, Abibatou; Vanga-Bosson, Abo Henriette; Miezan, Assohoun Jean Sebastien; Koné, Estelle Gnanyo Massafoma; Kassi, Fulgence Kondo; Kiki-Barro, Pulchérie M. Christiane; Angora, Etienne Kpongbo; Djohan, Vincent; Menan, Hervé EI; Yavo, William. 2026. "Increase in Adherence and Efficacy of Intermittent Preventive Treatment (IPT) with Sulfadoxine–Pyrimethamine Among Pregnant Women in Bouna from 2021 to 2024." AJPME 4, no. 2: 3.
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